Nausea is the sensation of unease
and discomfort in the stomach and is a symptom often associated with motion sickness, pregnancy, chemotherapy,
use of multiple medications such as HIV cocktails and postoperative surgery.
Mechanism of Action
Clinical
studies have shown that the herbal in DizzyStop® is believed to relieve or prevent nausea and vomiting by acting to decrease the release of the hormone responsible for causing nausea. Additionally, these studies reveal that the herbal in DizzyStop® acts to calm the contractions of the stomach and intestine. Research has shown that the herbal in DizzyStop® acts
to effectively control nausea equally or more effectively than prescription drugs
and without the side effects.
Directions for use of DizzyStop® for control of Nausea:
Take two capsules four times a day until nausea is resolved.
For persistent nausea, please consult your physician.
Six double blinded studies with 675 participants showed the herbal in DizzyStop® to be superior
to placebo in control of nausea of pregnancy without adverse side effects. Other studies showed pregnant women with nausea and
vomiting to have less nausea with the herbal in DizzyStop® than women taking placebo. The herbal in DizzyStop® is
effective in relieving the severity of nausea and vomiting of pregnancy without adverse effect on pregnancy outcome.
1: Brett White, American Family Physician, June 2007
2: Portnoi et al Am Journal ObGyn, 2003, pp.1374-1377
3: VUTAYANICH et al, Obstetrics and Gynecology, 2001, vol 97pp.577-582
4: Aust N Z J Obstet Gynaecol. 2003 Apr;43(2):139-44.
Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial.
Willetts K.E., Ekangaki A., Eden JA. School of Women and Children's Health, University of
New South Wales, Royal Hospital for Women, Randwick, New South Wales, Australia.
OBJECTIVE: To investigate the effect of a ginger extract (EV.EXT35)
on the symptoms of morning sickness.
DESIGN: Double-blind randomised placebo-controlled trial.
SETTING: A tertiary metropolitan teaching hospital, March 1999-November 1999.
PARTICIPANTS: The participants included
120 women less than 20 weeks pregnant, who had experienced morning sickness daily for at least a week and
had had no relief of symptoms through dietary changes.
INTERVENTION: Random allocation of 125 mg ginger
extract (EV.EXT35; equivalent to 1.5 g of dried ginger) or placebo given four times per day for 4 days.
MAIN OUTCOME MEASURES: Nausea, vomiting and retching
as measured by the Rhodes Index of Nausea, Vomiting
and Retching.
RESULTS: The nausea experience score was significantly less for the ginger extract group
relative to the placebo group after the first day of treatment and this difference was present for
each treatment day. Retching was also reduced by the ginger extract although to a lesser extent. No
significant effect was observed on vomiting. Follow-up of the pregnancies revealed normal ranges
of birthweight, gestational age, Apgar scores and frequencies of congenital abnormalities when the
study group infants were compared to the general population of infants born at the Royal Hospital
for Women for the year 1999-2000.
CONCLUSION: Ginger can be considered as a useful treatment option
for women suffering from morning sickness.
5: Obstet Gynecol. 2004 Apr;103(4):639-45.
A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy.
Smith C , Crowther C , Willson K . Department of Obstetrics and Gynaecology, The
University of Adelaide, Adelaide, Australia.
OBJECTIVE: To estimate whether the use of ginger to treat nausea or vomiting
in pregnancy is equivalent to pyridoxine hydrochloride (vitamin B6).
METHODS:A randomized, controlled equivalence trial involving 291
women less than 16 weeks pregnant was undertaken at a teaching hospital in Australia. Women took 1.05 g
of ginger or 75 mg of vitamin B6 daily for 3 weeks. Differences from baseline in nausea and vomiting scores
were estimated for both groups at days 7, 14, and 21.
RESULTS:Ginger was equivalent to vitamin B6 in reducing nausea
(mean difference 0.2, 90% confidence interval [CI] -0.3, 0.8), retching (mean difference 0.3; 90% CI -0.0,
0.6) and vomiting (mean difference 0.5; 90% CI 0.0, 0.9), averaged over time, with no evidence of different
effects at the 3 time points.
CONCLUSION:For women looking for relief from their nausea, dry
retching, and vomiting, the use of ginger in early pregnancy will reduce their symptoms to an equivalent
extent as vitamin B6.
6: Obstet Gynecol. 2001 Apr; 97(4): 577-82.
Ginger for nausea and vomiting in pregnancy:
randomized, double-masked, placebo-controlled trial.
Vutyavanich T, Kraisarin T, Ruangsri R. Department
of Obstetrics and Gynecology, Chiang Mai University , Chiang Mai, Thailand.
OBJECTIVE: To determine the effectiveness of ginger for the treatment of nausea and vomiting of pregnancy.
METHODS: Women with nausea and vomiting of pregnancy, who first
attended an antenatal clinic at or before 17 weeks' gestation, were invited to participate in the study.
During a 5-month period, 70 eligible women gave consent and were randomized in a double-masked design
to receive either oral ginger 1 g per day or an identical placebo for 4 days. Subjects graded the severity
of their nausea using visual analog scales and recorded the number of vomiting episodes in the previous
24 hours before treatment, and again during 4 consecutive days while taking treatment. At a follow-up
visit 7 days later, five-item Likert scales were used to assess the severity of their symptoms.
RESULTS:All participants except three in the placebo group
remained in the study. The visual analog scores of posttherapy minus baseline nausea decreased
significantly in the ginger group (2.1 +/- 1.9) compared with the placebo group (0.9 +/- 2.2, P =.014).
The number of vomiting episodes also decreased significantly in the ginger group (1.4 +/- 1.3) compared
with the placebo group (0.3 +/- 1.1, P <.001). Likert scales showed that 28 of 32 in the ginger group had
improvement in nausea symptoms compared with 10 of 35 in the placebo group (P <.001). No adverse effect
of ginger on pregnancy outcome was detected.
CONCLUSION:Ginger is effective for relieving the severity of
nausea and vomiting of pregnancy.
